Advancing proteomics with ion/ion chemistry

Advancing proteomics with ion/ion chemistry.

Mass spectrometers, instruments that use electric and/or magnetic fields to measure a gas-phase ion's mass-to-charge ratio (m/z), are used in a wide variety of applications--with the field having a reputation for providing good sensitivity and high-informing power. Protein analysis (proteomics) is a relatively recent affair for the field and was enabled in the late 1980s with the advent of biom...

Chemistry. Chemistry in a computer: advancing the in silico dream.

Perspectives of peptide chemistry and combinatorial chemistry for proteomics

The main scientific objective of the project is to promote and facilitate proteomics studies by developing new technologies for the analysis of proteins in complex mixtures, that are complementary to conventional 2-dimensional gel electrophoresis. To reach this goal, the design, analytical development and industrial fabrication of a complete platform is pursued comprising a new generation of au...

Advancing Cell Biology Through Proteomics in Space and Time (PROSPECTS)*

The term "proteomics" encompasses the large-scale detection and analysis of proteins and their post-translational modifications. Driven by major improvements in mass spectrometric instrumentation, methodology, and data analysis, the proteomics field has burgeoned in recent years. It now provides a range of sensitive and quantitative approaches for measuring protein structures and dynamics that ...

Advancing cardiovascular biology and medicine via proteomics: Opportunities and present challenges of cardiovascular proteomics.

The successful advancement of biology and medicine necessitates a comprehensive and integrative understanding of the proteome in a healthy individual and, through inference, the identification of those proteins considered to be abnormal and to potentially herald disease. Protein markers, complementary to gene markers, constitute the molecular basis for personalized medicine. Given the enormity ...